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lung-derived normal human microvascular endothelial cells (hmvec-l  (Lonza)


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    Lonza lung-derived normal human microvascular endothelial cells (hmvec-l
    BMEC-1 (A) and <t>HMVEC-L</t> (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human <t>microvascular</t> endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Lung Derived Normal Human Microvascular Endothelial Cells (Hmvec L, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lung-derived normal human microvascular endothelial cells (hmvec-l/product/Lonza
    Average 90 stars, based on 1 article reviews
    lung-derived normal human microvascular endothelial cells (hmvec-l - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Alteration in Endoglin-Related Angiogenesis in Refractory Cytopenia with Multilineage Dysplasia"

    Article Title: Alteration in Endoglin-Related Angiogenesis in Refractory Cytopenia with Multilineage Dysplasia

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0053624

    BMEC-1 (A) and HMVEC-L (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human microvascular endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Figure Legend Snippet: BMEC-1 (A) and HMVEC-L (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human microvascular endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).

    Techniques Used: Concentration Assay, Incubation, Inverted Microscopy, Derivative Assay



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    lung-derived normal human microvascular endothelial cells (hmvec-l  (Lonza)
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    Lonza lung-derived normal human microvascular endothelial cells (hmvec-l
    BMEC-1 (A) and <t>HMVEC-L</t> (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human <t>microvascular</t> endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Lung Derived Normal Human Microvascular Endothelial Cells (Hmvec L, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lung-derived normal human microvascular endothelial cells (hmvec-l/product/Lonza
    Average 90 stars, based on 1 article reviews
    lung-derived normal human microvascular endothelial cells (hmvec-l - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    normal human lung microvascular endothelial cells (hmvec-l)  (Lonza)
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    Lonza normal human lung microvascular endothelial cells (hmvec-l)
    BMEC-1 (A) and <t>HMVEC-L</t> (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human <t>microvascular</t> endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Normal Human Lung Microvascular Endothelial Cells (Hmvec L), supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/normal human lung microvascular endothelial cells (hmvec-l)/product/Lonza
    Average 90 stars, based on 1 article reviews
    normal human lung microvascular endothelial cells (hmvec-l) - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    normal human microvascular endothelial cells (lung) hmvec-l  (Lonza)
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    Lonza normal human microvascular endothelial cells (lung) hmvec-l
    BMEC-1 (A) and <t>HMVEC-L</t> (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human <t>microvascular</t> endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Normal Human Microvascular Endothelial Cells (Lung) Hmvec L, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/normal human microvascular endothelial cells (lung) hmvec-l/product/Lonza
    Average 90 stars, based on 1 article reviews
    normal human microvascular endothelial cells (lung) hmvec-l - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    lung-derived normal human microvascular endothelial cells hmvec-l  (Lonza)
    90
    Lonza lung-derived normal human microvascular endothelial cells hmvec-l
    BMEC-1 (A) and <t>HMVEC-L</t> (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human <t>microvascular</t> endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Lung Derived Normal Human Microvascular Endothelial Cells Hmvec L, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lung-derived normal human microvascular endothelial cells hmvec-l/product/Lonza
    Average 90 stars, based on 1 article reviews
    lung-derived normal human microvascular endothelial cells hmvec-l - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    normal human lung microvascular endothelial cells hmvec l  (Lonza)
    97
    Lonza normal human lung microvascular endothelial cells hmvec l
    BMEC-1 (A) and <t>HMVEC-L</t> (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human <t>microvascular</t> endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).
    Normal Human Lung Microvascular Endothelial Cells Hmvec L, supplied by Lonza, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/normal human lung microvascular endothelial cells hmvec l/product/Lonza
    Average 97 stars, based on 1 article reviews
    normal human lung microvascular endothelial cells hmvec l - by Bioz Stars, 2026-02
    97/100 stars
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    Image Search Results


    BMEC-1 (A) and HMVEC-L (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human microvascular endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).

    Journal: PLoS ONE

    Article Title: Alteration in Endoglin-Related Angiogenesis in Refractory Cytopenia with Multilineage Dysplasia

    doi: 10.1371/journal.pone.0053624

    Figure Lengend Snippet: BMEC-1 (A) and HMVEC-L (B) were seeded at a concentration of 8,000 cells per well of 96-well plate and incubated for 7 h at 37°C in 5% CO 2 . The endothelial tube formation was photographed at 5 h using a phase contrast inverted microscope. Each experiment was performed in duplicate. The pictures show the appearance of endothelial cell tubes on Matrigel® precoated plates in culture medium (i) and BM supernatant fluid from healthy control (ii), RA (iii), RARS (iv), 5q syndrome (v), RAEB (high-risk MDS) (vi) and RCMD (vii-viii) patients at 1∶10 dilution in culture medium. As the arrows show in the figure, the tube morphology was strikingly influenced by BM supernatant fluid from MDS (iii-viii) with respect to the controls (ii). The tubes originated after the incubation of BMEC-1 or HMVEC-L with the BM supernatant fluid from RCMD patients (vii-viii) were almost completely disrupted and formed closed capillary networks. MDS: myelodysplastic syndrome; BM: bone marrow; BMEC-1: bone marrow endothelial cells; HMVEC-L: lung-derived normal human microvascular endothelial cells; RA: refractory anemia; RARS: refractory anemia with ring sideroblast; RAEB refractory anemia with excess of blasts; RCMD: refractory cytopenia with multilineage dysplasia. (Controls n = 13; RA n = 5; RARS n = 6; 5q syndrome n = 2; RAEB n = 4; RCMD n = 7).

    Article Snippet: Lung-derived normal human microvascular endothelial cells (HMVEC-L) were purchased from Clonetics (Lonza Walkersville, MD, USA) and maintained exactly as recommended by the manufacturer.

    Techniques: Concentration Assay, Incubation, Inverted Microscopy, Derivative Assay